Talk:Tadalafil

Initial comments

This article states that Lilly bought Icos in 2006. That is incorrect. Icos still has not been purchased and maybe never will.----

Eli Lilly purchased ICOS Corporation for $2.3 billion dollars in 2007.71.113.78.21 (talk) 12:59, 10 February 2008 (UTC)

As with Levitra, I just had to put that bit in about what to do if a certain body part remains hard for more than four hours.

JesseG 00:31, 16 Jun 2004 (UTC)

Levitra and cialis difference

Levitra and cialis both are PDE5 inhibitors and in which way do they differ in performance, price, customer satisfaction, Any clarifications please? alongside the clarifications information regrading more drug ingeractions if any would be important,does it have any effect on the bone marrow? — Preceding unsigned comment added by 175.110.134.250 (talk) 08:48, 11 September 2011 (UTC)

Levitra is not used much, so studies comparing "customer satisfaction" have been done between the more widely used Cialis and Viagra, and have not shown much difference. The main difference between the 3 drugs (Levitra, Viagra, and Cialis) is the duration of action/pharmacologic half-life of Cialis, which is mentioned in the article. Levitra and Cialis have similar pharmacologic properties (half-life, duration of action, time of onset) and efficacy, with Cialis being more widely used due to "first to market" and familiar branding71.113.78.21 (talk) 13:02, 10 February 2008 (UTC)

Comparison with other drugs

I've made a request for more information about how this drug compares to similar ones. I think other people would like to know more about this too. Thanks to anyone who can help. Eje211 16:57, 9 May 2006 (UTC)

A great in-depth article can be found here, in which the three drugs are compared. Tadalafil has a different binding-mode than Sildenafil or Vardenafil, which are structurally very similar.

Cialis Drug History cleanup

The section is confusing; it talks about Pfizer as if it were a drug, whereas Pfizer is the company that owns Viagra. The statement that Cialis works for up to 36 hours occurs twice in the last two sentences. And the whole thing needs to sourced. -- Donald Albury 10:17, 28 October 2006 (UTC)

cleaning...

Corrected the confusion between company (Pfizer) and drug (Viagra). The statement about the effect duration depends on the half-life of the substance. Both the mesured halfe-life and the advertised effect duration can be found in any drug data base. The problem is : most drug database are restricted to physician. The few public I know are in french. I don't know which source to mention here. Help ! DrYak 13:36, 24 November 2006 (UTC)

If you don't know of any publicly accessible source in English, cite a French one. If someone finds a source in English, it can always be added then. .-- Donald Albury 16:48, 24 November 2006 (UTC)

Niagara means 'waterfall' in latin??

According to this article the word "Niagara" means 'waterfall' in latin. But according to the Niagara Falls article, "The name "Niagara" is said to originate from an Iroquois word "Onguiaahra" meaning "The Strait." " SO WHATS THE DEAL???

Another reading of that sentence is that the name Viagra is derived from the Latin vita and from the name of the waterfall, which does not imply that 'Niagara' is from Latin. However, the whole thing is unsourced. -- Donald Albury 11:05, 26 November 2006 (UTC)

Spam

How about a section that says something like "Cialis has a bad reputation for being offered through spam"? --71.125.20.130 21:39, 15 December 2006 (UTC)

As opposed to all the other drugs that are not offered through e-mail spam? -- Donald Albury 02:20, 17 December 2006 (UTC)

Mostly this and Viagra are in spam, I would say it's significant and notable 84.9.98.2 08:53, 2 May 2007 (UTC)

Causes erections?

"...caused the heart patients that were participating in a clinical study of a heart medicine to have erections..."

Surely this is wrong or incorrectly phrased?

The FDA-approved package insert[1] for Cialis says "Some form of sexual stimulation is needed for an erection to happen with CIALIS." Dpbsmith (talk) 13:10, 30 December 2006 (UTC)

Slightly incorrectly phrased. As part of the clinical development procedure, all drugs go through a First in Man clinical trial. As it's the first time the drug has been tested in humans, all partipants are healthy young males.

As any young male can testify, you don't really need much stimulation to obtain an erection, let alone with chemical assistance. If you're still skeptical, bear in mind that FIM trials are usually closely monitored by medical staff, which include nurses. :) Oni no Akuma 07:11, 12 September 2007 (UTC)

Ooops, forgot to mention, this was how sildenafil was discovered. The line you've highlighted is discussing the history of viagra and how that drug has affected the development of cialis. Oni no Akuma 11:11, 13 September 2007 (UTC)

The aforementionned statement "Some form of sexual stimulation is needed for an erection to happen with CIALIS" is correct. The pivotal clinical trials conducted with Cialis were in men with erectile dysfunction, and "spontaneous erections" were rare (as indicated in the label). After Cialis use, sexual stimulation is required to initiate an erection. 71.113.78.21 (talk) 13:11, 10 February 2008 (UTC)

Unique SMILES formula

Should anyone want to add it to the infobox (with | smiles=<formula>), the Unique SMILES formula is

CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c5ccc6OCOc6c5)C1=O

71.41.210.146 05:12, 29 April 2007 (UTC)

encouraging competition

The article, presumably sponsored by Eli Lilly omits to mention that other brands of Tadalafil are available e.g. Forzest from Ranbaxy Pharmaceuticals.

Tadalafil is still under patent by Eli Lilly and a generic version is not available by Ranbaxy Pharmaceuticals. Similarly, Forzest is one of many "online" pharmacies located outside of the US that advertises "generic tadalafil".71.113.78.21 (talk) 13:11, 10 February 2008 (UTC)

Also confirmed that "Some form of sexual stimulation is needed for an erection to happen with Tadalafil"

Mechanisms of action

the part at the end where it says that:

"Right heart failure and pulmonary oedema are the main consequences of pulmonary arterial hypertension"

is incorrect. Right heart failure causes edema of the extremities, not the lungs, —Preceding unsigned comment added by User38934 (talk • contribs) 01:14, 10 May 2008 (UTC)

Ta-DA!

How did it come to be called TADA-lafil; and, "See Alice"? Pawyilee (talk) 09:47, 1 October 2008 (UTC)

Vision and Hearing Loss

Hmmm... Is it like "beer goggles"? "V goggles" <==> "blurry vision"; she'll do; I don't want to waste the erection!

"Hank, how come you an Alice got so many kids?", asked Hank's friend. Hank replied "Well, it's because I'm hard of hearing. Every night before we go to sleep, Alice asks me if I want to go to sleep now or what, and I say `what'?" —Preceding unsigned comment added by 76.27.101.194 (talk) 22:01, 7 January 2009 (UTC)

Erectile Dysfunction vs. Impotence

This article, like several others, makes the mistake of equating erectile dysfunction (ED) with impotence. The latter is more often psychological in origin and in fact, the subject may be in perfect physical health and physically able to achieve a satisfactory erection if aroused. On the other hand, most men suffering from ED alone can be sexually aroused, experience orgasm and ejaculate, even though they are not able to become erect. If the subject has psychological or emotional issues that interfere with becoming sexually aroused, the entire supply of Cialis and Viagra in the known universe will be of no use. Bigdumbdinosaur (talk) 17:40, 11 December 2008 (UTC)

That's wrong. Erectile dysfunction is a synonym for male impotence. In fact impotence redirects to erectile dysfunction. —Preceding unsigned comment added by Qemist (talk • contribs) 23:25, 7 December 2009 (UTC)

Drug interactions

Nitrates or nitrites? the first sentence refers to nitrates but the second specifies a nitrite. I believe the interaction is with nitrites. Qemist (talk) 23:31, 7 December 2009 (UTC)

Biased against buyout

The paragraph below sounds biased and is unsourced. Is there a better way to word this while still conveying the info?

In 2007, Eli Lilly and Company bought the ICOS Corporation for 2.3 billion dollars. As a result, Eli Lilly owned Cialis and then closed the ICOS operations, ending the joint venture and firing most of ICOS's approximately 500 employees, except for 127 employees of the ICOS biologics facility, which subsequently was bought by CMC Biopharmaceuticals A/S(CMC).

Um... Nope!! There's not really any honest way to write about firing 500 people - after a buyout, no less - without making it seem like a not so nice thing to do.

Chemistry section

I have removed the chemistry section because it was just a diagram and reference with no context and no explanation whatsoever. Here is the removed content if anyone wants to use it:
File:Tadalafil syn.png Dunn, P. J.; Org. Proc. Res. Devel. 2005, 9, 88. http://dx.doi.org/10.1021/op040019c
ChemNerd (talk) 14:45, 10 August 2010 (UTC)

New hope for Peyronie's sufferers?

A recent study concludes that low-dose daily Cialis is a safe and effective treatment option in penile scar remodeling.

Find it here:

www.ncbi.nlm.nih.gov/pubmed/21324095 —Preceding unsigned comment added by 24.236.86.191 (talk) 01:00, 22 March 2011 (UTC)

Chemical diagram

Please forgive me for posting at the top, I have no idea of talk page etiquette but the molecular diagram seems to be missing all its hydrogen atoms.Moggyland (talk) 22:06, 11 January 2012 (UTC)

The diagram is a skeletal formula and is the standard way that organic chemists depict chemical compounds such as tadalafil. -- Ed (Edgar181) 22:08, 11 January 2012 (UTC)

I was referring not to the top diagram but to the one below, I've never seen one like that missing all its hydrogens before. Moggyland (talk) 22:12, 11 January 2012 (UTC)

Oh, sorry. Hydrogen atoms are usually shown in that type of three-dimensional structure, but they are sometimes left out for clarity because it is the carbon framework rather than hydrogen atoms that contributes most to the overall geometry. To me it doesn't seem necessary to omit them here, but shouldn't be harmful because anyone with the chemical knowledge to understand and/or use the diagram will recognize that the hydrogen atoms are implicit. -- Ed (Edgar181) 22:19, 11 January 2012 (UTC)

Many thanks for explaining the finer points. I have little knowledge of chemistry but it just didn't look right to me. Moggyland (talk) 22:26, 11 January 2012 (UTC)

dosage

Cialis also comes in 2.5 Milligram dosage 173.70.174.112 (talk) 15:31, 17 January 2012 (UTC)

Central Asian Kingdom?

This article currently starts with this: "Cialis" redirects here. For the Central Asian kingdom, see Karasahr.

I went to that page and I cannot for the life of me discern how or why these two articles are related. Could someone offer an explanation? I presume there must be one, but if not maybe it should be removed? -- MyNameWasTaken (talk) 23:09, 28 February 2012 (UTC)

Check Karasahr again. That article shows that the name "Cialis" appears on a 17th-century map, and was evidently "an Italianized transcription of the Turkic Chalish". This material has stood in the Karasahr article since October 2009, when the disamb. line you questioned was added to the Tadalafil article. -- NameIsRon (talk) 15:20, 10 November 2013 (UTC)

Patent issues and expirations

https://www.drugs.com/availability/generic-cialis.html

https://www.drugpatentwatch.com/p/tradename/CIALIS

ee1518 (talk) 20:35, 2 February 2018 (UTC)

Marketing

America's Cup is not a golf event. The link points to the sailing trophy. 70.143.71.3 (talk) 22:17, 6 January 2014 (UTC)

Dubious

If priapism is a concern, a short half-life should be preferred, not a longer one. Samsara 06:46, 21 November 2016 (UTC)

Enteric coating?

This article mentions the tablets are "enteric coated" (without any citation). We recently had a patient who inquired about splitting the tablets, I phoned up Eli Lilly and Company (NZ) Limited and they said the Cialis-brand tablets are NOT enteric-coated, there is NO sustained-release formulation whatsoever. They only cannot recommend halving the tablets because they haven't done any bioavailablity studies. All the sources I can find only mentions the tablets are "film-coated". Observation (talk) 03:42, 21 May 2017 (UTC)

References

After a serious search, I can find no evidence that tablets are enteric coated, and have found substantial evidence that it is not, e.g., studies of dissolution in simulated gastric juice. I have removed the unsupported claim.109.150.226.71 (talk) 12:06, 15 July 2017 (UTC)

Wholesale cost

The article currently states that the wholesale cost is $45 (U.S. dollars). Is that correct? Does that mean for one pill? That does not seem correct, but I could be wrong. Thanks. Joseph A. Spadaro (talk) 19:30, 24 May 2019 (UTC)

The article states: In the UK it costs the NHS about 0.80 £ per dose as of 2019. In the United States the wholesale cost of this amount is about 45 USD. Joseph A. Spadaro (talk) 19:31, 24 May 2019 (UTC)

The lead

Should be written in easier to understand language per WP:MEDMOS. Doc James (talk · contribs · email) 23:19, 9 June 2019 (UTC)

Two different sources in one footnote

The following reference

<ref name="tadalafil">{{cite journal|date=October 9, 2003|title=The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues|url=https://pubs.acs.org/doi/full/10.1021/jm0300577|journal=[[Journal of Medicinal Chemistry]]|volume=46|issue=21|pages=4525–32|doi=10.1021/jm030056e|pmid=14521414|via=|vauthors=Daugan A, Grondin P, Ruault C, Le Monnier de Gouville AC, Coste H, Kirilovsky J, Hyafil F, Labaudinière R}}</ref>

is linking to one article with the URL and a different (but similarly named article) with its doi. The URL was added afterwards by another user, so I've reverted that and replaced the content of the footnote with the details of the oringial article which was added to support the claim in the article. Jonatan Svensson Glad (talk) 23:01, 12 April 2020 (UTC)