Talk:Structural biology

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Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 14 January 2019 and 18 May 2019. Further details are available on the course page. Student editor(s): Jajc1128.

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Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 19 January 2021 and 16 April 2021. Further details are available on the course page. Student editor(s): Ghuske. Peer reviewers: Notjustbio.

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Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 31 August 2021 and 16 December 2021. Further details are available on the course page. Student editor(s): Ae2526. Peer reviewers: Cs4652, Magggey.

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Proposed Changes

I'm planning to add a small history section, covering a few moments in structural biology. In particular, brief mentions of Max Von Laues early X-Ray crystallography work, and the finding of the structure of Myoglobin. I was also considering condensing the methods listed at the start into their own techniques/methods section. Let me know if there is any opposition to these changes, or suggestions. Ghuske (talk) 14:31, 2 April 2021 (UTC)[reply]

In the next couple weeks, I am planning to add more to the history section, explaining key advances in the field due to computational work, such as protein structure prediction with AlphaFold^[1]. I also want to create an application section with insights on topics such as how structural biology can help us understand protein aggregation diseases^[2]. Please let me know if you have any oppositions or suggestions regarding these changes. Ae2526 (talk) 20:23, 7 November 2021 (UTC)[reply]

I expanded the history section and added an application section with a total of eight more references to the article. Let me know if anyone has any comments about any of these changes. Ae2526 (talk) 04:44, 7 December 2021 (UTC)[reply]

References

^ Jumper, John; Evans, Richard; Pritzel, Alexander; Green, Tim; Figurnov, Michael; Ronneberger, Olaf; Tunyasuvunakool, Kathryn; Bates, Russ; Žídek, Augustin; Potapenko, Anna; Bridgland, Alex; Meyer, Clemens; Kohl, Simon A. A.; Ballard, Andrew J.; Cowie, Andrew; Romera-Paredes, Bernardino; Nikolov, Stanislav; Jain, Rishub; Adler, Jonas; Back, Trevor; Petersen, Stig; Reiman, David; Clancy, Ellen; Zielinski, Michal; Steinegger, Martin; Pacholska, Michalina; Berghammer, Tamas; Bodenstein, Sebastian; Silver, David; Vinyals, Oriol; Senior, Andrew W.; Kavukcuoglu, Koray; Kohli, Pushmeet; Hassabis, Demis (26 August 2021). "Highly accurate protein structure prediction with AlphaFold". Nature. 596 (7873): 583–589. doi:10.1038/s41586-021-03819-2.
^ Eisenberg, David; Nelson, Rebecca; Sawaya, Michael R.; Balbirnie, Melinda; Sambashivan, Shilpa; Ivanova, Magdalena I.; Madsen, Anders Ø.; Riekel, Christian (1 September 2006). "The Structural Biology of Protein Aggregation Diseases: Fundamental Questions and Some Answers". Accounts of Chemical Research. 39 (9): 568–575. doi:10.1021/ar0500618.

Untitled

Good definition, I miss the term "molecular", though. Structural biology most certainly is not anatomy or morphology. Sjoerd de Vries

Merger proposal

I propose that Biomolecular structure be merged into Structural biology. Both are fundamentally the same and the latter is more comprehensive and common in usage. Chhandama (talk) 08:45, 5 February 2018 (UTC)[reply]

Oppose merging. Biomolecular structure is about the relevant structures themselves; Structural biology is about the scientific discipline of studying those structures, which is a separate topic in and of itself. The second paragraph of the article on Structural biology lists techniques for detecting and measuring characteristics of biomolecules (mass spectrometry, etc.); the article on Biomolecular structure only gets to a section on "Structural determination" after several sections on the structures themselves. In general, where there is a well-developed scientific discipline devoted to the study of X, that discipline should have its own article, separate from the article on X.

—Syrenka V (talk) 09:15, 14 February 2018 (UTC)[reply]

I also oppose merging, for the above and other reasons. But Syrenka V's point highlights the fact that the two articles are not really divided currently by technique vs the molecules, and especially that neither one discusses at all the huge disciples of macromolecular crystallography, NMR, and cryoEM which have dominated this work for more than 50 years and are even more exciting currently. I don't have the time right now, but I will try soon to provide at least a framework that other editors could expand.Dcrjsr (talk) 15:42, 14 February 2018 (UTC)[reply]

Hi Dcrjsr! I agree that a clearer, sharper topical division between the two articles would be an improvement (although it is appropriate for each article to have a very brief description of the topic of the other, along with a link). I would also welcome and appreciate more current and comprehensive information on the techniques of study that you mention; that would be a great improvement to the article.

—Syrenka V (talk) 10:16, 21 February 2018 (UTC)[reply]

Please connect this value with Danish value of “Molekylærbiologi”

Can someone please connect this value with the Danish one named Molekylærbiologi.

Structural Biology and Molecular biology are similar 84.111.208.114 (talk) 12:06, 17 May 2022 (UTC)[reply]

[1] Jumper, John; Evans, Richard; Pritzel, Alexander; Green, Tim; Figurnov, Michael; Ronneberger, Olaf; Tunyasuvunakool, Kathryn; Bates, Russ; Žídek, Augustin; Potapenko, Anna; Bridgland, Alex; Meyer, Clemens; Kohl, Simon A. A.; Ballard, Andrew J.; Cowie, Andrew; Romera-Paredes, Bernardino; Nikolov, Stanislav; Jain, Rishub; Adler, Jonas; Back, Trevor; Petersen, Stig; Reiman, David; Clancy, Ellen; Zielinski, Michal; Steinegger, Martin; Pacholska, Michalina; Berghammer, Tamas; Bodenstein, Sebastian; Silver, David; Vinyals, Oriol; Senior, Andrew W.; Kavukcuoglu, Koray; Kohli, Pushmeet; Hassabis, Demis (26 August 2021). "Highly accurate protein structure prediction with AlphaFold". Nature. 596 (7873): 583–589. doi:10.1038/s41586-021-03819-2.

[2] Eisenberg, David; Nelson, Rebecca; Sawaya, Michael R.; Balbirnie, Melinda; Sambashivan, Shilpa; Ivanova, Magdalena I.; Madsen, Anders Ø.; Riekel, Christian (1 September 2006). "The Structural Biology of Protein Aggregation Diseases: Fundamental Questions and Some Answers". Accounts of Chemical Research. 39 (9): 568–575. doi:10.1021/ar0500618.

[1]

[2]